St. Bernard was laid out in 1851 at the intersection of Main Street (now Vine Street, Cincinnati), the Miami and Erie Canal, and the Cincinnati, Hamilton and Dayton Railway.

[7] St. Bernard along with Norwood and Elmwood Place, is an enclave surrounded by the city of Cincinnati.

35.3% of all households were made up of individuals, and 11.7% were someone living alone who was 65 years of age or older.

[14] As of the census[15] of 2010, there were 4,368 people, 1,869 households, and 1,090 families living in the village.

There were 2,128 housing units at an average density of 1,372.9 per square mile (530.1/km2).

36.2% of all households were made up of individuals, and 12.8% had someone living alone who was 65 years of age or older.

There were 2,195 housing units at an average density of 1,424.7 per square mile (550.1/km2).

34.5% of all households were made up of individuals, and 14.5% had someone living alone who was 65 years of age or older.

St. Bernard has a joint public school district with the neighboring Village of Elmwood Place.

St. Bernard is served by a branch of the Public Library of Cincinnati and Hamilton County.