St. Brendan High School is a co-educational private Catholic high school in the Westchester census-designated place in Miami-Dade County, Florida.

St. Brendan High School was originally St. John Vianney Minor Seminary High School, which opened in 1959 to accept students who were interested in studying for the priesthood.

The school is primarily committed to serving the educational needs of the Catholic population of the southwest section of Miami.

In 1975, 346 students were enrolled in the ninth and tenth grades.

By 1977, 870 students were enrolled in the ninth, tenth, eleventh, and twelfth grades.