Saint Florian Taking Leave of the Monastery is an oil-on-panel painting by German artist Albrecht Altdorfer, dating from around 1518–1520.

The other five panels are in the Germanisches Nationalmuseum, in Nuremberg, in number of three, one is in the Národní Galerie, in Prague and the other is held in a private collection in Berlin.

The complete work was to resemble the Polyptych of the Stories of Saint Sebastian and of the Passion, painted by the same artist in Regensburg, for the collegiate church of Linz, in 1518.

[2][3] Saint Florian, a Roman soldier from Enns, according to the tradition, had defended the Christians of Upper Austria in 304, during emperor Diocletian persecutions, which led to his martyrdom by means of tying a grindstone around his neck and throwing him into the Inn River.

The story of the painting, inspired by Paracelsus, is easily readable, due to the popular and catchy style.