This led to the establishment of All Saints Hospital, located at Tenth and Campbell streets, on May 10, 1885, by Bishop Charles Franklin Robertson of the Episcopal Diocese of Missouri, but it closed in the 1890s.

[3][4] In October 1902, the first Saint Luke's hospital opened on the second and third floors of a store at Fifth and Delaware streets as a branch of Episcopalian charities.

The hospital contained 12 beds, a kitchen, an operating room, a laboratory, a reception area, and living quarters for the superintendent of nurses and two students.

The hospital was relocated in 1906 to Samuel Scott's large brick home on the southeast corner of Eleventh and Euclid streets, where it remained for approximately 17 years.

The hospital later moved to its current location on Country Club Plaza near Mill Creek Parkway and Wornall Road.