St. Matthews is a town in Calhoun County, South Carolina, United States.

[6] St. Matthews is part of the Columbia, South Carolina Metropolitan Statistical Area.

The town holds an annual Purple Martin festival in April which includes food, music, cars, and more.

Banks House, Buyck's Bluff Archeological Site, Calhoun County Courthouse, Calhoun County Library, Cherokee Path, Sterling Land Grant, Col. Olin M. Dantzler House, David Houser House, Prehistoric Indian Village, and Puritan Farm are listed on the National Register of Historic Places.

[5] Public education in St. Matthews is administered by Calhoun County School District.

[13] St. Matthews is home to the Calhoun County Museum, on Butler Street, which is run and directed by Mrs. Roland.

The Museum houses countless artifacts and stories of St. Matthews history and character.