In June 2005, under the support of Government of Russia, State Duma, Federation Council of Russia, Russian Rector's Union, the prize-winners of Golden Medal: European Quality competition in the nomination of Top 100 of Russian Universities were awarded.

Saint Petersburg State Pediatric Medical Academy was honored with a golden medal.

The main building of University was settled on the territory of City Children's Hospital, which had been founded in 1905.

The Children's Hospital was built as a series of separated pavilions to prevent spreading of infectious diseases.

[3] During the period of Russian Civil War(1918–1920) the hospital was neglected, but the large number of orphaned children after the war led authorities to provide more funding, and on January 7, 1925, the Scientific-Practical Institute of Maternity and Infancy Protection, named after Clara Zetkin, opened.

The country struggled with getting enough qualified medical specialists, and the child mortality still remained high.

There were somatic, surgical, infectious, neurological, tuberculosis, venereal, obstetric, gynecological departments in the institute.

Throughout all years of World War II, the institute continued clinical, research, educational and organizational work.

The majority of faculty and clinical staff remained in Leningrad, surrounded by German troops.

Medical students spend the first three years of training studying science, biomedical, liberal, and disease-preventive disciplines.