Saintia Shō was serialized in Akita Shoten's Champion Red magazine from August 2013 to July 2021, with its chapters collected in sixteen tankōbon released.

The main character in the series is a young female Saint named Shō, who protects Athena and her Sanctuary from the attack of Goddess of Discord, Eris.

The series introduces a new class of female Saints, which are known as Saintia (聖闘少女, Seintia, kanji for "Holy Fighting Girls", also romanized as Saint-ia), Athena's personal maidens.

Canis Major Sirius, Hound Asterion, Sagitta Ptolemy, Eagle Marin, and Ophiuchus Shaina also appear in Saint Seiya: Saintia Shō.

Sagittarius Aiolos, Pisces Aphrodite, Cancer Deathmask, Capricorn Shura, Aquarius Camus, Aries Mu, Taurus Aldebaran, and Virgo Shaka also appear in Saint Seiya: Saintia Shō.