The Church of the Holy Wisdom of God or Saint Sophia Church (Russian: Церковь Софии Премудрости Божией) ― was a Russian Orthodox church in Nakhchivan-on-Don (which currently form a part of Rostov-on-Don city) Rostov Oblast, Russia.

[1] Nakhichevan-on-Don was originally formed by Armenian settlers, but since the town was close to Rostov-on-Don, where the Russian population was predominant, Nakhichevan could not remain a mononational Armenian city for a long time.

Next to the place of the former St. Sophia Church, the building of School No.

[2] In the last years of the church's existence, the future Georgian Metropolitan Zinovy (Mazhuga) [ru] served there.

This article on an Eastern Orthodox church building in Russia is a stub.