It resides in a fifteen-story building located at 202 West 58th Street in midtown Manhattan, one block south of Central Park.

Designed by the architecture firm Buttrick White & Burtis, the $18 million, 55,000-square-foot (5,100 m2), steel-frame building was clad in red brick, with limestone trim and gray brick accents, rising six stories before stepping back twenty feet, then rising eight more stories to a gabled roof form containing a small chapel illuminated by a large circular window.

The principal feature of the lower facade is a three-story window (suggestive of an "oriel"), framed in buff Indiana limestone with red granite accents.

[7] In March 2024, Saint Thomas Church warned that due to rising costs, it would discontinue operating the school unless it raised $50 million in endowment funds.

Students also participate in an athletic program, competing against local private schools in soccer, basketball, and track.

The choir's primary raison d'être, however, is to provide music for five choral services each week at Saint Thomas Church.

[11] In addition to annual performances of Handel's Messiah, concerts at Saint Thomas Church have included requiems by Fauré, Brahms, Mozart, Duruflé, and Howells; Bach's Passions and Mass in B Minor; the Monteverdi Vespers of 1610; a Henry Purcell anniversary concert; Rachmaninoff Vespers; the U.S. premiere of John Tavener's Mass; a concert of American composers featuring works by Leonard Bernstein and Aaron Copland; a composition by Saint Thomas chorister Daniel Castellanos; the world premiere of Scott Eyerly's Spires; and a concert of works by Benjamin Britten.

The choir has toured throughout the U.S. and Europe, performing at Westminster Abbey and St. Paul's Cathedral in London; Kings College, Cambridge; Windsor Castle; Edinburgh; St. Albans; and at the Aldeburgh Festival.