It was dedicated in 1923, and its design replicates the Mission Puerto de Purísima Concepción, which once stood on the site.
Construction began on the Purísima Concepción Mission in the fall of 1780 by Fathers Juan Antonio Barreneche and Francis Tomás Hermenogildo Garcés.
Poorly defended, the mission was destroyed the following year, during a raid and massacre over the period of July 17–19, 1781 by Quechans (Yuma), frustrated by their treatment at the hands of the Spanish colonists.
The raid left fathers Garcés and Barreneche dead, beaten to death with clubs, over 100 Spanish settlers killed, and 74 more were held as prisoners until Governor Pedro Fages paid a ransom for their release in 1782.
The site of the mission was later part of Fort Yuma.