Sainte-Hermine (French pronunciation: [sɛ̃t ɛʁmin]) is a former commune in the Vendée department in the Pays de la Loire region in western France.

On 1 January 2025, it was merged into the new commune of Saint-Jean-d'Hermine.

[2] The river Smagne flows southwestward through the commune and crosses the town.

The river Lay forms most of the commune's northern border.

This Vendée geographical article is a stub.