Sainte-Marguerite-en-Ouche (French pronunciation: [sɛ̃t maʁɡərit ɑ̃.n‿uʃ], literally Sainte-Marguerite in Ouche) is a former commune in the Eure department in Normandy in northern France.

On 1 January 2016, it was merged into the new commune of Mesnil-en-Ouche.

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