From its origin in the Western Forest Complex in Nakhon Sawan, it is called Huai Pha Daeng (Thai: ห้วยผาแดง) and then Huai Duea (ห้วยเดื่อ);[2] while flowing along the border between Nakhon Sawan and Kamphaeng Phet provinces, it is known as Huai Mae Wong (ห้วยแม่วงก์) or Nam Mae Wong (น้ำแม่วงก์); while flowing through Nakhon Sawan again, it is sequentially called Nam Mae Wong, Nam Wang Ma (น้ำวังม้า) and Nam Tak Daet (น้ำตากแดด); it becomes the Tak Daet River (แม่น้ำตากแดด) while passing Sawang Arom and Thap Than districts of Uthai Thani, and while forming the border between Mueang Uthai Thani District of Uthai Thani and Krok Phra District of Nakhon Sawan.

The main tributaries of the Sakae Krang River include Huai Thap Salao and Khlong Pho.

The total land area drained by the Sakae Krang River is 5,191 square kilometres (2,004 sq mi).

[3] In 2011, after high rainfall and poor flood control management, much of the Sakae Krang River overflowed its banks between September and November that year.

The main riverside market in Uthai Thani City was under up to 160 centimetres (5 ft) of water for over seven weeks.