According to the National Center for Education Statistics, in 2021–2022, the school reported an enrollment of 665 pupils in grades 9th through 12th.

[1] Salem High School offers courses in the traditional American curriculum.

Entering their third and fourth years, students can elect to attend the Columbiana County Career and Technical Center in Lisbon as either a part time student, taking core courses at SHS, while taking career or technical education at the career center, or as a full time student instead.

Students may choose to take training in automotives, construction technology, cosmetology, culinary arts, health sciences, information technology, multimedia, landscape & environmental design, precision machining, veterinary science, and welding.

College Football Hall of Fame inductee Earle Bruce had his first head coaching position at Salem.