[2] Similar to humans, salmon calcitonin is a peptide hormone produced in the ultimobranchial region by parafollicular cells in response to hypercalcemia and lowers blood calcium and phosphate by promoting renal excretion.
Salcatonin is composed of 32 amino acids, of which 13 differ from human calcitonin.
It is used as therapy for Paget's disease, severe hypercalcemia, and in some cases, gynecomastia.
[2] Studies have shown that treatment of with salcatonin can reduce the rate of new fractures in the lumbar spine and the forearm in postmenopausal women.
Noninvasive sCT preparation as a nasal spray is commercially produced and received US FDA approval under the proprietary name Miacalcin® in 1975 for the treatment of postmenopausal osteoporosis.