Salt Creek is an unincorporated community and a census-designated place (CDP) located in and governed by Pueblo County, Colorado, United States.

The CDP is a part of the Pueblo, CO Metropolitan Statistical Area.

The population of the Salt Creek CDP was 507 at the United States Census 2020.

[3] The Pueblo post office (Zip Code 81006) serves the area.

[5] The Salt Creek CDP has an area of 277 acres (1.119 km2), all land.