Salt Creek is a tributary of the Arkansas River in Pueblo County, Colorado in the United States.

[2] The creek rises in arid rangeland southwest of Pueblo, Colorado.

At a point 2.3 miles (3.7 kilometers) west of Saint Charles Reservoir Number 3, the Minnequa Canal – which begins at a diversion dam on the Arkansas River 30 miles (48 kilometers) west of Pueblo near Florence, Colorado – empties into the creek, greatly increasing its flow.

Finally, the creek goes under Santa Fe Drive in Pueblo and then flows east along and south of the Arkansas River, passing through several ponds and channelized sections before emptying into the Arkansas River itself.

Residents upstream, including those in the Salt Creek neighborhood, are asking that exemptions the state of Colorado granted the mill in the 1970s be lifted, so that the mill is required to treat its wastewater before releasing it into the creek.