The main line of the East Broad Top Railroad (EBT) was built through Saltillo in 1874.

Saltillo was an important place on the EBT, acting as a base station for the long grade up to Broad Top Mountain.

The EBT had a three-track yard, a station, a water tank and a turning wye located here.

In 1942 a spur was built from the EBT yard in Saltillo, which climbed the mountain to a tipple below the quarry.

The water tank was burned by vandals in the late 1980s and the station was demolished in the mid-2000s after being allowed to deteriorate to deplorable condition.

Around 1935 the skeleton of a mastodon was discovered behind the ball field in Saltillo by two young men digging a drainage ditch.

The Hudson Grist Mill at the southwest edge of town was listed on the National Register of Historic Places in 1990.

According to the United States Census Bureau, the borough has a total area of 0.25 square miles (0.65 km2), all land.