Born in Catania, Pappalardo began his studies in his home city before entering the Palermo Conservatory where he studied under Pietro Raimondi.
He worked as a music teacher and was a conductor at the opera house in Catania until he moved to Naples in 1845 when he was made the court composer for Prince Leopold, Count of Syracuse.
He later worked as a teacher of music theory and composition in Naples.
His most successful and innovative music however, was his chamber music; particularly his collection of art songs for voice and piano and a collection of string quartets and quintets.
Secoli di musica catanese (Catania, 1968)