Salvia desoleana is a herbaceous perennial shrub native to the island of Sardinia in the Mediterranean.

Salvia desoleana was named for the botanist Luigi Desole, and was first described in 1982.

It is a low-growing plant with elongated rhizomatous roots that grow parallel to the ground.

The ovate leaves grow as large as 8 in long (200 mm) by 6 in wide (150 mm), with both surfaces covered with hairs and glands, releasing a strong fragrance when crushed or brushed.

The 1-foot inflorescences (0.30 m) have hairy stems, with evenly spaced whorls of six flowers, whose calyces include two 1-inch-wide (25 mm) leafy green bracts.