Sadigursky has performed or recorded with the Mingus Orchestra, Brad Mehldau, Gabriel Kahane, Fred Hersch, Tom Jones, Darcy James Argue, Linda Oh, Anat Fort, Joe Phillips, Michael Leonhart, Red Baraat, Nico Muhly, Judd Greenstein, Jamie Baum, Ljova and Max ZT.
Also prominent on the Latin music scene, he has performed with Edmar Castaneda, Lucia Pulido, Pablo Mayor's Folklore Urbano, Toto la Momposina, La Cumbiamba eNeYe, Sofia Rei, US Poet Laureate Robert Pinsky, Pedro Guirado, Emilio Teubal, Diego Obregon, Rebolu, Sebastian Cruz, and Roberto Rodriguez and the Cuban Jewish All Stars.
Sam released his first album as a leader in 2008, The Words Project, which consists of his original musical settings of poetry, and features vocalists Monika Heidemann, Becca Stevens, Heather Masse, and Noam Weinstein, along with Sadigursky (saxophone, clarinets, and alto flute), Pete Rende (piano/Rhodes/pump organ), Nate Radley (guitar), Eivind Opsvik (bass), Tommy Crane (drums), and Robert Burkhart (cello).
The album features settings of poems by Osip Mandelstam, Paul Auster, Marina Tsvetaeva, Czeslaw Milosz, Penelope Shuttle, Sylvia Plath, Donald Justice, and Maxine Kumin.
Sadigursky followed this album with Words Project II in 2010, which features settings of poems and texts by Langston Hughes, Audre Lord, Sadi Ranson, Andrew Boyd, David Ignatow, Czeslaw Milosz, and Dunya Mikhail.
The album features vocalists Monika Heidemann, Becca Stevens, and Wendy Gilles, along with Sadigursky (saxophone), Nate Radley (guitar/banjo), Pete Rende (piano/Rhodes/pump organ), Eivind Opsvik (bass), Bill Campbell (drums) and Richie Barshay (percussion).
It features settings of poems and words by Fernando Pessoa, Carl Sandburg, Bertold Brecht, George W. Bush, Sadi Ranson, and Spencer Reece.
In 2022, he released The Solomon Diaries, a three album set of original music inspired by the dramatic rise and fall of the Borscht Belt region, which features Nathan Koci on accordion.
The same year, he also released Figures/Broken Pieces, a set of 16 original piano works inspired by notable and interesting lives lost in 2020, featuring pianists Glenn Zaleski, Nick Sanders, and Dahveed Behroozi.