It is this experience that drives her older brother Fox Mulder to join the FBI, and later take the reins of the X-Files section.

Her older brother Fox Mulder, who was 12 years old at the time, witnessed the abduction that began his life-long obsession with finding the truth about extraterrestrials to shed light on this unexplained incident.

[2] Many episodes of the show focused on Mulder's determined efforts to discover what happened to his little sister and find out about her whereabouts or unveil her fate.

She tells Mulder that she has children of her own, thought that her mother had died some time ago, and believed the Cigarette Smoking Man to be her father.

Eventually, she was picked up by police as a wandering runaway and taken to Dominic Savio Memorial Hospital, suffering from paranoia and what authorities considered to be self-inflicted wounds.

Decades later, Ray informs Scully and Harold Pillar, the psychic, about the mysterious young girl (while Mulder stands nearby).

Ray adds that a group of men (seemingly including the Cigarette Smoking Man) came to the hospital to claim the girl, only to find out upon their arrival that she was gone, taken by "spiritual intervention" beings called "Walk-ins", which try to save the innocent souls of children who are due to suffer terrible fates.

[10] David Bell and Lee-Jane Bennion-Nixon described Samantha's story as a classical conspiracy narrative, and a "long-running, episodic storyline is especially pivotal to the series", a driving force behind the actions of its main character, Fox Mulder.