Because of their cover-up of extraterrestrial life, they were the primary antagonistic force opposing Dana Scully, Fox Mulder, John Doggett, and Monica Reyes during the series.
The Syndicate, operating at the highest levels of power, concealed from the world a program by an unidentified extraterrestrial species to colonize and repopulate the planet, as well as their own plans and stake in that future, which they held to be inevitable.
To carry out murder, cover-ups, sabotage and other wetworks projects, the Syndicate used an unknown number of henchmen commonly referred to as the Men in Black.
[1] However, most of the Syndicate's meetings were held at a nondescript building located on West 46th Street (with parallels to the Century Association and Ivy League alumni clubs) in New York City, and did not involve Strughold, due to the fact that his entry into the United States would potentially draw too much attention because of his ties to Nazi Germany.
Reportedly, series creator Chris Carter named the company after USA Today TV critic Matt Roush, who was an influential early champion of The X-Files.
[2] The Syndicate was formed at the end of World War II, after the Roswell incident 1947, when German scientists were brought to the United States to work on developing an alien-human hybrid.
Alvin Kurtzweil recounted that when he and Bill Mulder were young men in the military, they were recruited for a project that they were told was concerned with biological warfare.
Their activities included experimenting with xenotransplantation,[7] relocating ex-Nazi scientists to the United States after World War II,[8] and covering up the black oil discovered in the Piper Maru in 1953.
Outside of Washington, D.C., they attacked a train car, wherein a group of Syndicate doctors led by Eugene Openshaw were experimenting on Cassandra Spender—the first successful alien-human hybrid.
[14] Later on, Mulder dreamt of the Syndicate, in which an illusory version of the Cigarette Smoking Man claimed that his group had "made entire cultures disappear".
[16] In season eight, Doctor Lizzy Gill admitted to Mulder, Assistant Director Walter Skinner and Special agent John Doggett that, for the past ten years, she and her colleagues had been working to create a human-alien hybrid.
Gill's colleagues, by this time, included Doctors Parenti, Lev and Duffy Haskell, but they all had been killed recently by super soldier Billy Miles.
[21] In the eleventh season premiere "My Struggle III", Mulder encountered Mr. Y and his accomplice Erika Price, who claimed to be former members of the Syndicate with their own agenda involving the colonization of space and simulated reality.