Samarkand State Medical University was founded in May 1930 as the initiative of the Council of People's Commissars of the Uzbek SSR.
Scientific councils for awarding the academic degree of candidate and doctor of sciences have been created and are effectively functioning at SSMU.
In Samarkand State Medical University there are 83 departments, including courses where 624 scientists and teachers conduct scientific and pedagogical activities.
Clinical bases for students are also all medical and diagnostic institutions of the city of Samarkand, where in the future they undergo practical training.
According to the resolution of the President of the Republic of Uzbekistan Shavkat Mirziyoyev dated April 1, 2022 "On the establishment of Samarkand State Medical University and further improvement of the system of personnel training in this area", the following were established: Research Institute of Rehabilitation and Sports Medicine, Research Institute of Microbiology, Virology, Infectious and Parasitic Diseases named after L. M. Isaev, Republican Specialized Scientific and Practical Medical Center for Epidemiology, Microbiology, Infectious and Parasitic Diseases, Specialized Scientific and Practical Center for Neurosurgery and Neurorehabilitation, Scientific Center for Immunology, Allergology and Human Genomics.