An electronics expert by training, he has held a number of professional roles, including senior advisor to the Syrian banking industry and a member of the board of Syrian Arab Airlines.

[3] In July 2006, Khiyami announced to the London media that Syria was attempting to dissuade Hezbollah from continuing to launch rocket attacks on Israel, the latter being part of the claimed justification for Israel's July air strikes on Lebanon.

On April 28, 2011, Khiyami's invitation to Prince William's wedding was formally withdrawn due to Syria's violent response to protesters.

[5] He quit the diplomatic service shortly thereafter, citing the excessive use of violence of the Syrian governments against protesters as the reason for his resignation.

[6] According to German and Arabic media reports Khiyami is among the founding members of an initiative called the 'Council of the Syrian Charter' that unites elders and representatives from various Syrian families, clans, tribes and communities both inside and outside of Syria.