[2] The school was a few months old when the First World War broke out and the ensuing economic crisis meant that initially not all facilities could be used in order to save cost.

The school initially operated with gender separation and co-ed classes didn't become the norm until 1946.

The growth was projected to be lasting so in 1988 the school was expanded for 5.8 million Danish Kroner.

In 1998, Samsøgade School was one of 22 applicants among 793, and the only one in Aarhus, to be chosen for the information technology project IT Springet funded and supervised by the Danish Ministry of Education.

Former students include 2 former Danish prime ministers: Hans Hedtoft and H. C. Hansen Samsøgades School is a monumental 4 story building in the Gothic revival style, constructed of red brick on a basement of granite ashlar.