[2] His son, the third Samuel Dexter, served in the administrations of John Adams and Thomas Jefferson.

Dexter moved from Dedham to Boston and earned "a modest fortune" with his "mercantile pursuits.

"[3][5] He retired back to Dedham in 1761 at the age of 36 to build the Samuel Dexter House.

[11] Following the evacuation of Boston, General George Washington spent the night of April 4, 1776 at Dexter's home on his way to New York.

[12] In December 1771, Dexter hosted John Hancock and Jason Haven, his minister and brother-in-law, for dinner.