At the age of fourteen Newell went to Portland, and on sight-seeing tour he accepted an offer of a captain of a vessel that lay in the harbor; consequently, he moved to Boston.
[1][2][3] Newell graduated from Harvard College in 1807 and started working as an assistant teacher at the Grammar School in Roxbury; later, he took charge of the Academy at Lynn.
[1][2][3] Newell later studied medicine while awaiting passage to India, and was ordained along with Judson, Mills, Hall, Nott, and Rice in February 1812, by the ABCFM at Salem, Massachusetts.
In February 1812, he married Harriet Atwood, who had already joined Congregational church in 1809 and had developed interest in missions through Newell's courtship.
[1][2][3] Upon their arrival in Calcutta they were denied residence by British East India Company and were asked to leave; as a result Samuel and Harriet took a ship to Mauritius.