It was founded in 1992 at Sedqa, Independence Avenue, Naxxar, by the Parents Foundation of Education, who also founded the San Anton School.

San Andrea's Grade system differs from the one used in Malta's Government Schools (Year) as they are one grade higher for example "Year 10" would be "Grade 11".

The San Andrea School financial fraud was a highly publicized case of financial fraud involving the San Andrea School, a private educational institution located in Malta.

[1] The fraud was discovered in early 2019, after an investigation was launched by the school's board of governors and the Maltese authorities.

[2] This Malta school-related article is a stub.