Some historians claim that the town was begun by Dr Gaspar Rodríguez de Francia (1814–1840), who established a fortress to defend the Paraguayan territory.

San Antonio may have been founded in 1890 by the German citizen Gustavo Conrado Gotees (born Conrad Götz in Schnabelwald, Germany).

[1] Brazilian troops arrived in its ports, en route to the historical battle of Ytororó in December 1868.

San Antonio is located on the Paraguay River, latitude 25 38 and longitude 57 63 in the south center 25 km from the capital, Asuncion.

The river affects the weather, making the nights and early mornings fresh, and the days very hot.

In the city there are a great variety of trees such as the tajy or lapacho, trébol, pine, eucalyptus, cedar laurel and palm.

The first industry that was established in the city was the International Products Corporation (IPC) slaughterhouse, which was the primary employer in San Antonio and other towns in the area.

Founded May 30, 1917, it was a slaughterhouse for cattle, pigs and goats, with facilities to prepare and refrigerate with modern equipment.

In the 1960s many soccer teams were located there, including Cerro Porteño, Guaraní, Sol de America, Libertad and Sportivo Luqueño.

Years later, it was bought by industrialist Don Alberto Antebi, and production restarted on January 12, 1981, with modern equipment, Israel is one of the main customers.

In the morning, there is a mass, then the Nautical procession, with decorated canoes and other boats, with the patron image of San Antonio.

There is an annual Expo San Antonio to show artisan work of the inhabitants and the products of the different companies.