Mariano Roque Alonso (Spanish pronunciation: [maˈɾja.no ˈro.ke aˈlon.so]) is a district and city located in the Central Department, in Paraguay in the Gran Asunción metropolitan area.

This optimal location has allowed the city quick commercial, industrial, and social development.

The town is known because on the afternoon of February 4, 1996, LAC Colombia Flight 028 crashed while taking off from Silvio Pettirossi International Airport, killing the 4 crew and 18 people on the ground.

With 22 people dead, it is the worst air accident in the history of Paraguay.

Mariano Roque Alonso is home to the site of the biggest annual Expo show in Paraguay where companies and industries showcase their latest products.