The town is bordered by its sister communities of San Antonio Este, to the east, and Las Grutas, to the southwest.

Water scarcity led the original settlement to fail in 1905, leading the community to settle west of the gulf, in what today is San Antonio Oeste.

San Antonio Oeste benefited afterwards from a growth in tourism in nearby Las Grutas, a scenic cove known for its grottoes.

Since 2000, it has also been home to a growing fishing industry, resulting from the opening of a deep-water port in San Antonio Este.

[3] Temperatures can regularly fall below freezing during the winter months although snowfalls rarely occur, averaging 0.2 days with snow per year.