The church was founded in the 12th century at the site of an original 5th-century chapel dedicated to San Marino.
The first chapel on the right has a detached fresco, depicting the Madonna, brought here in 1807 from the Convent of the Cappuccini.
At one time the main altarpiece was a St Marino and Saints now found in the Chapel of Leo XII in Spoleto.
The frescoes in the choir depict the Life of St Marino (1595) by Giorgio Picchi.
To the right of the presbytery is a monument by Antonio Trentanove dedicated to Pope Pius VI, who stayed in the adjacent convent in 1782, while travelling to Vienna.