The Inland Empire 66ers of San Bernardino are a Minor League Baseball team of the California League and the Single-A affiliate of the Los Angeles Angels.

The 66ers began when the Salinas Spurs moved to San Bernardino and bought the name of the San Bernardino Spirit from the Rancho Cucamonga Quakes who had just left town.

In September 2006, the 66ers announced they were renewing its affiliation with the Los Angeles Dodgers beginning in the 2007 season.

[4] On December 15, 2024, following the sale of the Modesto Nuts franchise to Diamond, it was announced the 66ers would become the Class A affiliate of the Seattle Mariners beginning in the 2026 season; the move would consist of the current 66ers franchise assuming the place of the Modesto Nuts in a de facto relocation of the Nuts franchise (which would effectively cease operations at that time following a failure to receive funds to renovate their current stadium); the pre-2025 incarnation of the 66ers would then relocate to Rancho Cucamonga, assuming the identity of the Rancho Cucamonga Quakes; that team's pre-2025 team incarnation will then relocate to a new stadium being built in Ontario.

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