San Biagio (Saint Blaise) is a Roman Catholic church located on via Francesco Randazzo #24 in the town of Nicosia, in the province of Enna, region of Sicily, Italy.
The exterior of the church is nondescript flat with a large cornice over a rectangular stone portal.
The church has a single nave; the interior is richly decorated in late-Baroque stucco with gilded accents, completed by Serafino Perollo.
The main altar has five canvases completed by Giuseppe Velasco from 1772 to 1775: There is an altarpiece also on the topic of St Benedict by Velasco at the church of Concezione al Capo, Palermo.
Behind the canvas of St Blaise is an icon of the saint (1600) completed by Giovanni Battista Li Volsi, a sculptor native to Nicosia.