Located on the corner of Calle 10 and Carrera 5, the historic building has been the site of various political, social and academic events.

[1][2][3] The Palace of San Carlos The history of the building goes back to the end of the 16th century when it was built by Archdeacon Francisco Porras Mejia, in 1585.

[2] In 1767, after the Jesuits were expelled from New Granada by Francisco Antonio Moreno y Escandón [es], acting on orders from King Carlos III, it became the Royal Library of Santa Fe and served as barracks for the Presidential Guard.

[1] He was attacked when a group of conspirators attempted to assassinate him while he was taking a bath and he escaped through the window with soap still covering his body.

The event became known as the Noche Septembrina (English: September's Night), and it is referenced in Latin in a plaque conspicuously fixed on the wall next to the window through which he escaped.

The neighbouring oratory with works from the Santa Fe school and an altar in the colonial style with two florally decorated candelabras.

The large Audience Hall features a carpet with a hunting scene and carved wooden chairs with a gold-leaf finish.

There is a painting of the Virgin and Child from the Cuzco School and a 19th-century portrait of José Joaquín de Olmedo y Maruri, Minister of Foreign Affairs of Colombia, and later President of Ecuador, by A. Castillanos.