San Clemente High School is a Catholic high school in the Mayfield area of Newcastle, New South Wales, Australia.

In the year 1916 a small girls' school was founded by the Dominican Order of nuns in Kerr Street, Mayfield.

The school was moved to its current location in Havelock Street, and became a secondary school for young ladies, run by the sisters of St Dominic.

In 1977, the school became the first high school in the Diocese of Maitland-Newcastle to be run completely by lay staff, when the last Dominican sisters left, and the first lay principal was appointed.

In 2009, the school held a very formal opening ceremony joined by guests such as Bishop Michael Malone and Sharon Grierson, to celebrate the official opening of the new multimillion-dollar developments.