[3] Its watershed area covers Calamba and Cabuyao in Laguna, Tagaytay and municipality of Silang in Cavite.

The river system of San Cristobal from Mount Sungay is connected to the Matang Tubig located in Casile and Canlubang.

[4] Along with the San Juan River, the two rivers act as natural drainage systems by receiving and conveying Calamba's (and Cabuyao's for San Cristobal) liquid wastes and storm surface runoff to the nearby Laguna de Bay.

[1] Although a 1991 study cited the San Pedro River and Morong River as the sources of eutrophication-causing minerals in Laguna de Bay, the Laguna Lake Development Authority (LLDA) has noted that more recent deterioration of the San Cristobal River in Calamba have made it one of the lake's major sources of nutrient loading.

[5] The LLDA's conservation efforts for the major tributaries and watersheds of Laguna de Bay have led to the creation of the Laguna de Bay River Basin Councils, of which the San Cristobal River Enhancement Defenders (SACRED) is particularly tasked with conservation of the San Cristobal.