[5] Demolition of San Diego Stadium began in December 2020; its last freestanding section was felled on March 22, 2021.

[7] The Padres played home games at the stadium from their founding in 1969 through the 2003 season, then moved to Petco Park in downtown San Diego.

Additionally, the stadium hosted the San Diego Sockers of the North American Soccer League (NASL) from 1978 through the 1984 season.

It was the only stadium ever to host both the Super Bowl and the World Series in the same year (1998), and was one of three stadiums to host the Super Bowl, World Series, and the MLB All-Star Game, along with the Hubert H. Humphrey Metrodome in Minneapolis and the Los Angeles Memorial Coliseum in Los Angeles.

In November 1965, a $27 million bond was passed allowing construction to begin on a stadium, which was designed in the Brutalist style.

San Diego Stadium had a capacity of around 50,000; the three-tier grandstand was in the shape of a horseshoe, with the east end low (consisting of only one tier, partially topped by a large scoreboard).

[9] This was replaced in 1987 by a White Way Sign scoreboard, in which the video screen is surrounded almost entirely by three message boards.

However, this renovation relegated the Padres within their own stadium, as the city gave the Chargers full financial control of the 113 luxury suites.

With the departure of the Padres to Petco Park following the 2003 season and even beforehand, there was much talk of replacing the increasingly obsolete (by NFL standards) stadium with a more modern, football-only one.

[18] On December 27, 2019, the stadium hosted the San Diego County Credit Union Holiday Bowl, a college football bowl game between Iowa and USC (Iowa won the game), this was the final sporting event ever played at the stadium.

In order to accommodate the dimensions of both football and baseball fields, the stadium was constructed with half of the lower (Field Level) level seating built of permanent concrete (in the southern quadrant of the stadium), and the other half of portable modular construction using aluminum or steel framing.

From their inception in 1969 until the end of 2003, when they moved into Petco Park in the downtown area, the National League's San Diego Padres called the stadium home.

A 19-foot (5.8 m) wall, whose top was the rim of the Plaza level, surrounded the outfield, making home runs difficult to hit.

In 1996, a note of asymmetry was introduced when a 19-foot (5.8 m) high scoreboard displaying out-of-town scores was erected along the right-field wall near the foul pole and deemed to be in play, and so the distances to right field and right-center field were 330 feet (100 m) and 370 feet (110 m), respectively, while the remaining dimensions remained the same.

Orel Hershiser broke Don Drysdale's scoreless inning streak at Jack Murphy Stadium on September 28, 1988, as the Los Angeles Dodgers played the San Diego Padres.

The Chargers won all their games at the stadium against the Detroit Lions (5–0—0) and Jacksonville Jaguars (4–0—0), but lost all their meetups against the Atlanta Falcons (0–6—0), Carolina Panthers (0–3—0), and Green Bay Packers (0–6—0).

The Chargers moved to Dignity Health Sports Park in Carson, a suburb of Los Angeles, following the 2016 NFL season.

On October 27, 2018, the Navy Midshipmen hosted the Notre Dame Fighting Irish at the stadium for a regular season game.

CIF San Diego Section Finals for high school football were held at the stadium.

These usually took place on a Friday in early December, and four games were played (with eight teams representing four separate divisions, which are determined by the enrollment sizes of the individual schools).

The stadium also hosted several international friendlies featuring clubs such as Real Madrid, Chivas, Portsmouth F.C.

In 2019, the stadium hosted matches of National Independent Soccer Association club San Diego 1904 FC.

[41] In October 1967, just weeks after the stadium opened, it hosted a Sports Car Club of America event organized by San Diego Region.

In July 1968, the Region organized a SCCA National for the car park, now called the San Diego Stadium International Raceway, but the combination of a very small crowd and complaints about the noise ensured that the experiment was not repeated.

[43] Old Mission Beach Athletic Club RFC played rugby union at the adjacent mini-stadium, so-called Little Q.

[47] Concerts on the Green was a sports field converted into a music and entertainment venue, located on the southwest corner of the stadium parking lot.

Not only is Big SoCal Euro one of the largest all European car gatherings, but it is also one of the oldest events of its kind, established in 2002.

[50] A new stadium broke ground on the site one week later and ultimately opened in 2022 as Snapdragon Stadium, with a seating capacity of 35,000 to support events including SDSU football, non-football NCAA championship games, professional soccer, a possible future NFL team, and special events such as concerts.

[56] On March 22, 2021, the last freestanding section of San Diego Stadium visible from Interstates 8 and 15 was felled, leaving the plaza level to be demolished.