San Domenico is a Renaissance and Gothic style, consecrated Roman Catholic church and former monastery.
[1] The church contains mostly fragmentary and restored frescoes inside; in 1911 many of the Baroque additions to the structure were removed.
On the left side of the nave are three chapels with pointed arch entrances, one of which is dedicated to the Fallen in War and retains a 14th-century fresco depicting the Crucifixion with the Virgin and St John.
The main altar of the church contains the tomb of Blessed Margaret (1287-1320), Dominican tertiary, called the Blind of Metola, from the place where she was born.
The adjacent convent still maintains its 17th-century cloister, recently acquired by the City of Città di Castello The lunettes of the inner arches were frescoed between 1662 and 1667, depicting the Life of the Blessed Margherita.