San Domenico is a Gothic architecture, Roman Catholic church located on Piazza Ventinove Marzo in Orvieto, Umbria, central Italy.

Putatively this was the site of the former pagan temple of Minerva, and subsequently of the parish church named Santa Pace.

Construction of a Dominican monastery and church here begun in 1233 about a decade after the death of Dominic de Guzmán, and a year prior to his canonization.

[1] The original San Domenico and the monastery was enlarged under the papacy of Urban IV by cardinal Annibaldo Annibaldeschi.

The church is notable for housing the desk used by St Thomas Aquinas for his lessons at Orvieto during his sojourn in the city (1263–1264), as well as the Monument to Cardinal De Braye, sculpted by Arnolfo di Cambio around 1282.