San Domenico di Guzman is a cardinal-deaconry (titular church for a Cardinal-deacon) and parish church in Rome, dedicated to Saint Dominic of Guzman.

The church at Via Vincenzo Marmorale 25, in the tenth prefecture of northern Rome, was consecrated on 2 December 2000, to pastorally serve a parish created on 9 February 1977 in the Pope's own Diocese of Rome.

The title was established as cardinal-deaconry (i.e. for a cardinal-deacon) on 18 February 2012.

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