Presently it remains a parish church, owned by the Jesuit order, though focusing on religious works.

Located in Saint Fedele Square in the centre of the city, near the Palazzo Marino, the Teatro alla Scala and the Galleria Vittorio Emanuele II, the church was commissioned by Charles Borromeo from Pellegrino Tibaldi (1559).

The interior is decorated with artworks that include a Pietà by Simone Peterzano, a St. Ignatius by Giovanni Battista Crespi (il Cerano) a Transfiguration by Bernardino Campi, and a Sacred Heart by Lucio Fontana.

The Jesuit priest, Arcangelo Favaro, founder of the Galleria San Fedele, was prompted by the speech given by Pope Paul VI in 1964 urging a dialogue between art and faith.

Other works by David Simpson, Mimmo Paladino, Jannis Kounellis, Sean Shanahan, Claudio Parmiggiani, and Nicola De Maria are in the gallery or church.