A church at the site, dedicated to St John, was present since perhaps the seventh century, since nearby Christian burials appear to date from then.
In 1824, the Franciscans returned, and they rebuilt the church in a neoclassic-style, adding the Facade, under the design of Ferraris in 1835, completed in 1854.
The broad brick facade (1835–1854) shows eclectic styles with a triangular lower tympanum and monumental order pilasters.
The interior houses an Immaculate Conception by il Moncalvo; an Adoration of the Magi by Raffael Angelo Soleri; and a Madonna and Child with Saint Francis and Antony of Padua by Pietro Beccaria.
[3] The ceilings were frescoed by the 19th-century painter Pietro Ivaldi, detto il Muto di Toleto.