Acqui Terme (Italian pronunciation: [ˈakkwi ˈtɛrme]; Piedmontese: Àich [ˈɑi̯k]) is a city and comune in the province of Alessandria, Piedmont, northern Italy.

[3] The city's hot sulphur springs have been famous since this was the Roman town of Aquae Statiellae; the ancient baths are referred to by Paulus Diaconus and the chronicler Liutprand of Cremona.

During the Roman period, the region was connected by road with Alba Pompeia and Augusta Taurinorum (Turin) and was populated by the local Celto-Ligurian tribe of the Statielli.

The region was subject to Roman rule after their main center, Carystum (Acqui Terme), was attacked in 173 BC by the legions led by the consul Marcus Popilius Laenas.

The Statielli did not oppose resistance, but in contravention of the Roman law of war, the consul killed thousands of them, reduced the other Gauls to slavery, and began to organize the sale of slaves from the population.