San Francesco is a medieval, Gothic style, Roman Catholic church in the comune of Grosseto, Tuscany, Italy.

The portal has a rose window depicting the Madonna and child and saints, restored in 1927, along with bell tower, by the artist-architect Giuseppe Casucci.

The chapel on right is dedicated to St Anthony of Padua, and was decorated with Baroque frescoes (1651-1680) by Francesco Nasini and his brother Antonio.

[1] The church faces the small Chiesa dei Bigi, formerly part of a Clarissan convent.

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