In 1506, the icon is said to have performed miracles, leading to the foundation of the Confraternity or Compagnia di Misericordia associated with the church of Santi Stefano e Niccolao in Pescia.
To the right of the main altar is the chapel of St Charles Borromeo with a canvas by Rodomonte di Pasquino Pieri, a pupil of Pietro da Cortona.
In the third altar to the right was tempera painting on wood with an early portrait of St Francis surrounded by a series of scenes depicting his miracles (1235) by Bonaventura Berlinghieri.
The other chapel has a 15th-century triptych depicting the Madonna and Child with Saints Anne, Simon, Thaddeus, Lawrence, and Dominic.,[5] some sources attributed the painting to Spinello Aretino.
In the chapel of Sant'Antonio (of Padua), in the apse left of the main altar, are two paintings, one of the Miracle of the Kneeling Mule (wherein a heretic's mule knelt before St Antony administering the eucharist) by Giovanni Martinelli; the other is St Antony resurrects a deceased man, a copy of a work by Lorenzo Pasinelli found in the church of San Francesco, Bologna.
In the apse, the Cardini (or Orlandi-Cardini) chapel is entered through an elegant arch flanked by columns, all in pietra serena; it was designed by Andrea Cavalcanti, a pupil of Brunelleschi, and built in 1451-1458.
This chapel was found to have quattrocento-period frescoes, attributed to Neri di Bicci, depicting the brothers Cardini in prayer with the patrons of the town and valley.