In the early part of his life he worked in Florence as an assistant to his master Jacopo while painting frescoes in the church of the Carmine and in Santa Maria Novella.
[6] In 1391-1392 Spinello was painting six frescoes, which still remain on the south wall of the Pisan Campo Santo, representing miracles of St. Potitus and St. Ephesus.
[6] Spinello's frescoes are all strong and highly decorative works, drawn with much spirit, and are very superior in style to his panel pictures, many of which appear to be mere bottega productions.
[citation needed] The academy of Florence possesses a panel of the Madonna and Saints, which is chiefly interesting for its signature Hoc opus pinxit Spinellus Luce Aritio D.I.A.
[6] One of the highlights of his late career is a cycle of frescos on the life of Pope Alexander III made for the Sala di Balia of the Palazzo Pubblico in Siena.There is an important painting by Spinello Aretino in the Cleveland Museum of Art,"Virgin and Christ Child[7] With Angels".