[1] Above the main altar, now enclosed in a baroque marble frame consisting of clouds, putti, and angels, is an early 14th century painted icon depicting a Madonna and Child.

There is an altarpiece depicting the "Miracle of San Francesco di Paola crossing the Straits of Messina on his Mantle" (1711) by Alessandro Gherardini.

[3] Two paintings are no longer in the church: the Circumcision of Christ (1490-91) by Luca Signorelli and the stunning masterpiece of the Deposition (1521) by Rosso Fiorentino; the former is in the National Gallery of London, while the latter has been moved to the Pinacoteca Civica of Volterra.

This Gothic-style chapel was built in 1315 by architect Mone Todirigi for a confraternity (Compagnia della Croce di Giorno).

These frescoes were inspired by those of Agnolo Gaddi in the Santa Croce of Florence, and the Golden Legend of Jacobus de Voragine.