Its main peculiarity are the two "open sky" double mullioned windows in the façade, which are the first example of a model often repeated in northern Italy in the 14th and 15th centuries.
The wide interior is on the Latin cross plan, divided into a nave and two aisles with four spans each; there are also side chapels.
[1] In the right aisles are 16th-century frescoes depicting Madonna with St. Francis, St. Bonaventure and a Donor by the local painter Sebastiano Galeotti, a collaborator of Callisto Piazza.
Among the 16th- and 17th-century paintings are included a Saint Anthony meeting Ezzelino III da Romano by il Malosso, St. Francis Receiving the stigmata by Sollecito Arisi and a Madonna of Caravaggio by Enea Salmeggia.
The church contains the tombs of several notable people, including the poet Ada Negri and the naturalist Agostino Bassi.